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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence as outlined by a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it one should err on the side of caution and allow FDA do its job and demand some investigation be done so your public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say almost anything to keep people on his or her medications.

Researchers found out that participants using this drug for a year, lost weight within a month and have kept the load off through the entire 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more effective and safer.

Combo-pilling is the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that since right now there are not any long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure level and heart rate, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high blood pressure level, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed in the liver after that uptake from your intestines and contains no therapeutic effect. Buprenorphine will be the active substance; it can be absorbed under the tongue (and through the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who have had gastric bypass, the location where the first part of the intestine is bypassed and the stomach contents empty right into a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the process with normal anatomy where the drug is taken up with the duodenum and transferred right to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be adopted by portions of the intestine that aren't served with the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.